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Journal of Child Neurology
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Pyridoxine Dependency Seizures

Report of a Case With Unusual Features

Ross E. Pettit, MD

Department of Neurology, Grand Forks Clinic, Ltd, Grand Forks, ND, Division of Neurology, University of North Dakota School of Medicine, Fargo, ND

Pyridoxine dependency is a rare cause of neonatal seizures. Newborns with this disorder are often hyperirritable and fail to respond to the usual anticonvulsants. The diagnosis is established by cessation of seizures after the administration of parenteral pyridoxine. Reported is a case of pyridoxine dependency that illustrates several problems in management. The amount of pyridoxine required to control seizures is variable and may exceed 100 mg per day. The electroencephalogram (EEG) may not change significantly during the initiation of therapy. During intercurrent illnesses, parenteral pyridoxine may need to be given. Additional pyridoxine may be needed even when the EEG is normal. Treatment should continue indefinitely. (J Child Neurol 1987;2;38-40).

Journal of Child Neurology, Vol. 2, No. 1, 38-40 (1987)
DOI: 10.1177/088307388700200107
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This article has been cited by other articles:


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