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Journal of Child Neurology
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An Unusual Case of Neonatal Myasthenia

John Z. Heckmatt, MB, ChB, MRCP, MD

Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London

Monica Placzek, MB, ChB, MRCP, DCH

Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London

Anne H. Thompson, MB, ChB, MRCP

Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London

Victor Dubowitz, MD, BSc, MRCP, DCH

Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London

Graham Watson, BSc, MD, PhD, FRCP, DCH

Department of Paediatrics, Royal Free Hospital School of Medicine, London

An unusual case of neonatal myasthenia gravis is reported in an infant who had respiratory failure due to diaphragmatic weakness. Although power and tone in the limbs were normal, fatiguability of both diaphragm and peripheral muscles was demonstrated. Acetylcholine receptor antibodies were absent in the mother, which suggests that an alternative humoral mechanism may have been responsible for the transient (6-week) neonatal weakness. (J Child Neurol 1987;2:63-66)

Journal of Child Neurology, Vol. 2, No. 1, 63-66 (1987)
DOI: 10.1177/088307388700200112
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Home page
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G. Ahlsten, A.-K. Lefvert, P.-O. Osterman, E. Stalberg, and J. Safwenberg
Follow-up Study of Muscle Function in Children of Mothers With Myasthenia Gravis During Pregnancy
J Child Neurol, July 1, 1992; 7(3): 264 - 269.
[Abstract] [PDF]