This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Johnsen, S. D. Articles by Lotze, T. E. Search for Related Content PubMed PubMed Citation Articles by Johnsen, S. D. Articles by Lotze, T. E. Social Bookmarking                   What's this?

Frequency and Nature of Cerebellar Injury in the Extremely Premature Survivor with Cerebral Palsy

Section of Child Neurology Children's Health Center and Barrow Neurological Institute, St Joseph's Hospital, Phoenix, AZ, s2johnsen{at}chw.edu.

John B. Bodensteiner, MD

Section of Child Neurology Children's Health Center and Barrow Neurological Institute, St Joseph's Hospital, Phoenix, AZ

Timothy E. Lotze, MD, PhD

Section of Child Neurology Department of Pediatrics, Baylor College of Medicine, Houston, TX

We report on the frequency and variable nature of magnetic resonance imaging—documented injury to the cerebellum in children with cerebral palsy who had survived a birth with a weight under 1000 g and/or a gestational age under 28 weeks. Thirty of 67 patients who had magnetic resonance images were found to have injury to the cerebellum. Those with cerebellar injury were much more likely to be microcephalic and to be unable to walk or talk. They did not demonstrate a greater frequency of observed injury to the cerebrum. From a larger collection of children with known cerebellar injury and cerebral palsy who had a history of being extremely premature, we found that 35 of 47 patients had prominent injury to the inferior cerebellum, suggesting infarction, whereas the remainder demonstrated varying degrees of cerebellar atrophy with or without asymmetry and four also had enlarged 4th ventricles. Injury to the cerebellum in the extremely premature survivor who has cerebral palsy is common and associated with a more adverse clinical picture. The etiology of this injury is obscure. (J Child Neurol 2005;20:60—64).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				N. Bednarek, A. Akhavi, C. Pietrement, F. Mesmin, G. Loron, and P. Morville Outcome of Cerebellar Injury in Very Low Birth-Weight Infants: 6 Case Reports J Child Neurol, August 1, 2008; 23(8): 906 - 911. [Abstract] [PDF]

				C. Limperopoulos and A. J. du Plessis Injury to the Developing Cerebellum: Mechanisms and Consequences NeoReviews, October 1, 2007; 8(10): e409 - e417. [Abstract] [Full Text] [PDF]

				C. Limperopoulos, H. Bassan, K. Gauvreau, R. L. Robertson Jr, N. R. Sullivan, C. B. Benson, L. Avery, J. Stewart, J. S. S. MD, S. A. Ringer, et al. Does Cerebellar Injury in Premature Infants Contribute to the High Prevalence of Long-term Cognitive, Learning, and Behavioral Disability in Survivors? Pediatrics, September 1, 2007; 120(3): 584 - 593. [Abstract] [Full Text] [PDF]

				L.M. Nagae, A.H. Hoon Jr., E. Stashinko, D. Lin, W. Zhang, E. Levey, S. Wakana, H. Jiang, C.C. Leite, L.T. Lucato, et al. Diffusion Tensor Imaging in Children with Periventricular Leukomalacia: Variability of Injuries to White Matter Tracts AJNR Am. J. Neuroradiol., August 1, 2007; 28(7): 1213 - 1222. [Abstract] [Full Text] [PDF]

				J. B. Bodensteiner and S. D. Johnsen Magnetic Resonance Imaging (MRI) Findings in Children Surviving Extremely Premature Delivery and Extremely Low Birthweight With Cerebral Palsy J Child Neurol, September 1, 2006; 21(9): 743 - 747. [Abstract] [PDF]