Journal of Child Neurology

 

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Journal of Child Neurology, Vol. 20, No. 12, 968-971 (2005)
DOI: 10.1177/08830738050200120701

Neuronal Migration Disorders

Pierre Gressens, MD,PhD

INSERM L1676, Paris, 75019 France, Université Paris 7, Faculté de Médecine Denis Diderot, Pédiatrique, Paris, France, gressens{at}rdebre.inserm.fr

Improvement in imaging techniques has provided new classifications of neuronal migration disorders and their diagnosis in the developing or adult brain. Control of neuronal migration involves different cell populations, including Cajal-Retzius neurons, subplate neurons, neuronal precursors, or radial glia. The integrity of multiple molecular mechanisms, such as cell-cycle control, cell-cell adhesion, interaction with extracellular matrix protein, neurotransmitter release, growth factor availability, platelet-activating factor degradation, peroxisomal metabolism, or transduction pathways, seems to be critical for normal neuronal migration. The present review focuses on animal models of neuronal migration disorders. (J Child Neurol 2005;20:968—971).


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