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Journal of Child Neurology
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Cerebrospinal Fluid Insulin-Like Growth Factor 1 Is Low in Acute and Chronic White-Matter Diseases of Children

Raili Riikonen, MD

Department of Child Neurology Children's Hospital, Kuopio University Hospital, Kuopio, Finland, raili.riikonen{at}uku.fi

Ursula Turpeinen, PhD

Laboratory Helsinki University Central Hospital, Helsinki, Finland

Insulin-like growth factor 1 increases both the number of oligodendrocytes and the amount of axonal myelin produced. The aim of this study was to see whether insulin-like growth factor 1 played a role in white-matter diseases of children. We studied insulin-like growth factor 1 in the cerebrospinal fluid of children with various white-matter diseases: (1) children with acute demyelinating events: acute disseminated encephalomyelitis (n = 5), acute transverse myelitis in multiple sclerosis (n = 1), and infarct of the medial cerebral artery causing secondary white-matter changes (n = 1), and (2) children with chronic diseases: delayed myelination (n = 3) and progressive leukodystrophies (n = 4). Insulin-like growth factor 1 was determined by radioimmunoassay with commercially available kits (Mediagnost, Tubingen, Germany). We found markedly lower concentrations of cerebrospinal fluid insulin-like growth factor 1 in the patients than in the 28 age-matched control children (P < .0005). Low cerebrospinal fluid insulin-like growth factor 1 can play a role in the pathology of both acute and chronic white-matter diseases of children. (J Child Neurol 2005;20:181—184).

Journal of Child Neurology, Vol. 20, No. 3, 181-184 (2005)
DOI: 10.1177/08830738050200030201
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