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Journal of Child Neurology
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Pediatric Refractory Partial Status Epilepticus Responsive to Topiramate

Lubov Blumkin, MD

Pediatric Neurology Unit

Tally Lerman-Sagie, MD

Pediatric Neurology Unit

Tzion Houri, MD

Pediatric Intensive Care Unit

Eli Gilad, MD

Pediatric Intensive Care Unit

Andrea Nissenkorn, MD

Pediatric Neurology Unit Wolfson Medical Center Holon, Israel Sackler School of Medicine Tel Aviv University Tel Aviv, Israel

Mira Ginsberg, MD

Pediatric Neurology Unit Wolfson Medical Center Holon, Israel Sackler School of Medicine Tel Aviv University Tel Aviv, Israel

Nathan Watemberg, MD

Pediatric Neurology Unit Wolfson Medical Center Holon, Israel Sackler School of Medicine Tel Aviv University Tel Aviv, Israel, nwatemberg{at}pol.net

Topiramate was safely administered to two young children with refractory partial status epilepticus via nasogastric tube in rapid titration up to a very high total daily dose. An excellent clinical response occurred in both cases. Reaching high daily doses of topiramate within days allowed for safe discontinuation of other antiepileptic drugs in both patients. Given the high efficacy of rapidly titrated topiramate in our patients, this medication may be useful in some cases of pediatric refractory partial status epilepticus. However, more clinical studies on this therapeutic approach are needed to establish the precise role of topiramate in status epilepticus in children.( J Child Neurol 2005;20:239—241).

Journal of Child Neurology, Vol. 20, No. 3, 239-241 (2005)
DOI: 10.1177/08830738050200031701
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 Journal of Pharmacy PracticeHome page
S. S. Chung, N. C. Wang, and D. M. Treiman
Comparative Efficacy and Safety of Antiepileptic Drugs for the Treatment of Status Epilepticus
Journal of Pharmacy Practice, April 1, 2007; 20(2): 137 - 146.
[Abstract] [PDF]