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Journal of Child Neurology
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Childhood Case of Progressive Multifocal Leukoencephalopathy With Improved Clinical Outcome

Ercan Demir, MD

Department of Pediatric Neurology Hacettepe University Ankara, Turkey

Uwe G. Liebert, MD, PhD

Institute of Virology University of Leipzig Leipzig, Germany

Figen Söylemezoglu, MD

Department of Pathology Hacettepe University Ankara, Turkey

Kalbiye Yalaz, MD

Department of Pediatric Neurology Hacettepe University Ankara, Turkey

Gülsen Köse, MD

Department of Pediatric Neurology Social Security Children's Hospital Ankara, Turkey

Banu Anlar, MD

Department of Pediatric Neurology Hacettepe University Ankara, Turkey, banlar{at}hacettepe.edu.tr

A 6-year-old boy who had been in remission from acute lymphoblastic leukemia for 2.5 years presented with seizures, hemiparesis, visual loss, and white- and gray-matter lesions on cranial magnetic resonance imaging. The diagnosis of progressive multifocal leukoencephalopathy was established on the detection of JC virus DNA by polymerase chain reaction in brain tissue. The patient was administered several anticonvulsants, amantadine, acyclovir, and ganciclovir. He showed partial recovery. This case illustrates the possibility of long-term survival in progressive multifocal leukoencephalopathy with normal immunologic parameters. (J Child Neurol 2005;20:241—244).

Journal of Child Neurology, Vol. 20, No. 3, 241-244 (2005)
DOI: 10.1177/08830738050200031301
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