This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Shiraishi, H. Articles by Halgren, E. Search for Related Content PubMed PubMed Citation Articles by Shiraishi, H. Articles by Halgren, E. Social Bookmarking                         What's this?

Dynamic Statistical Parametric Mapping for Analyzing the Magnetoencephalographic Epileptiform Activity in Patients With Epilepsy

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, siraisi{at}nmr.mgh.harvard.edu., Department of Pediatrics, Hokkaido University, Graduate School of Medicine, Sapporo, Japan

Steven M. Stufflebeam, MD

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA

Susanne Knake, MD

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA

Seppo P. Ahlfors, PhD

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA

Akira Sudo, MD, PhD

Department of Pediatrics, Hokkaido University, Graduate School of Medicine, Sapporo, Japan

Naoko Asahina, MD

Department of Pediatrics, Hokkaido University, Graduate School of Medicine, Sapporo, Japan

Kiyoshi Egawa, MD

Department of Pediatrics, Hokkaido University, Graduate School of Medicine, Sapporo, Japan

Keisaku Hatanaka, PhD

Department of Applied Physics, Okayama University of Science, Okayama, Japan

Shinobu Kohsaka, MD, PhD

Department of Pediatrics, Hokkaido University, Graduate School of Medicine, Sapporo, Japan

Shinji Saitoh, MD, PhD

Department of Pediatrics, Hokkaido University, Graduate School of Medicine, Sapporo, Japan

P. Ellen Grant, MD

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA

Anders M. Dale, PhD

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA

Eric Halgren, PhD

MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA

Our current purpose is to evaluate the applicability of dynamic statistical parametric mapping, a novel method for localizing epileptiform activity recorded with magnetoencephalography in patients with epilepsy. We report four pediatric patients with focal epilepsies. Magnetoencephalographic data were collected with a 306-channel whole-head helmet-shaped sensor array. We calculated equivalent current dipoles and dynamic statistical parametric mapping movies of the interictal epileptiform discharges that were based in the minimum-L2 norm estimate, minimizing the square sum of the dipole element amplitudes. The dynamic statistical parametric mapping analysis of interictal epileptiform discharges can demonstrate the rapid change and propagation of interical epileptiform discharges. According to these findings, specific epileptogenic lesion—focal cortical dysplasia could be found and patients could be operated on successfully. The presurgical analysis of interictal epileptiform discharges using dynamic statistical parametric mapping seems to be promising in patients with a possible underlying focal cortical dysplasia and might help to guide the placement of invasive electrodes. (J Child Neurol 2005;20:363—369).

Journal of Child Neurology, Vol. 20, No. 4, 363-369 (2005)
DOI: 10.1177/08830738050200041601


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. Hara, F.-H. Lin, S. Camposano, D.M. Foxe, P.E. Grant, B.F. Bourgeois, S.P. Ahlfors, and S.M. Stufflebeam Magnetoencephalographic Mapping of Interictal Spike Propagation: A Technical and Clinical Report AJNR Am. J. Neuroradiol., September 1, 2007; 28(8): 1486 - 1488. [Abstract] [Full Text] [PDF]