Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kirton, A.
Right arrow Articles by Wirrell, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kirton, A.
Right arrow Articles by Wirrell, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Acute Necrotizing Encephalopathy in Caucasian Children: Two Cases and Review of the Literature

Adam Kirton, MD

Division of Pediatric Neurology Departments of Pediatrics and Clinical Neurosciences University of Calgary

Kevin Busche, MD, FRCPC

Department of Clinical Neurosciences University of Calgary

Catherine Ross, MD, FRCPC

Division of Pediatric Critical Care Department of Pediatrics University of Calgary

Elaine Wirrell, MD, FRCPC

Division of Pediatric Neurology Departments of Pediatrics and Clinical Neurosciences University of Calgary Calgary, Alberta, Canada, elaine.wirrell{at}calgaryhealthregion.ca

Acute necrotizing encephalopathy is a fulminant neurologic disease seen predominantly in Japan and Taiwan. We present two cases diagnosed at a Canadian center within the same year in Caucasian children. Both were previously well, developed an acute viral illness with fever and vomiting, and progressed to brain death within 2 to 4 days. Neuroimaging and postmortem examination demonstrated the unique features of bilateral and severe necrosis of deep gray-and subcortical white-matter structures. The first case was associated with extensive, but transient, hepatic involvement, recent varicella and rotavirus infections, and detailed metabolic studies, including mitochondrial functional analysis, were normal. The second case tested positive for influenza A infection, whereas evidence of liver damage was lacking. Both children demonstrated early lymphopenia and myocardial necrosis, two features not previously associated with acute necrotizing encephalopathy. These cases are unique in their occurrence in non-Japanese children and are among the first published reports in Canada. (J Child Neurol 2005;20:527-532).

Journal of Child Neurology, Vol. 20, No. 6, 527-532 (2005)
DOI: 10.1177/088307380502000612
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Virol.Home page
N. Feng, B. Kim, M. Fenaux, H. Nguyen, P. Vo, M. B. Omary, and H. B. Greenberg
Role of Interferon in Homologous and Heterologous Rotavirus Infection in the Intestines and Extraintestinal Organs of Suckling Mice
J. Virol., August 1, 2008; 82(15): 7578 - 7590.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
K. Sugata, K. Taniguchi, A. Yui, F. Miyake, S. Suga, Y. Asano, M. Ohashi, K. Suzuki, N. Nishimura, T. Ozaki, et al.
Analysis of Rotavirus Antigenemia and Extraintestinal Manifestations in Children With Rotavirus Gastroenteritis
Pediatrics, August 1, 2008; 122(2): 392 - 397.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
R Surtees and C DeSousa
Influenza virus associated encephalopathy
Arch. Dis. Child., June 1, 2006; 91(6): 455 - 456.
[Full Text] [PDF]