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Interleukin-1, Interleukin-1ß, and Interleukin-1Ra Polymorphisms in Febrile Seizures

enay Haspolat, MD

Departments of Pediatric Neurology, Akdeniz University Medical School, Antalya, Turkey, shaspolat{at}akdeniz.edu.tr

Yunus Baysal, MD

Pediatrics, Akdeniz University Medical School, Antalya, Turkey

Özgür Duman, MD

Departments of Pediatric Neurology, Akdeniz University Medical School, Antalya, Turkey

Mesut Cokun, MSc

Pediatric Immunology, Akdeniz University Medical School, Antalya, Turkey

Özgür Tosun

Biostatistics, Akdeniz University Medical School, Antalya, Turkey

Olcay Yein, MD

Pediatric Immunology, Akdeniz University Medical School, Antalya, Turkey,

Febrile seizures are the most common form of childhood seizures. The exact mechanism promoting convulsions during a common febrile illness remains unknown, but it is accepted that genetic influences are likely to account for at least some of the cases. Previous studies reported high interleukin-1ß levels in the cerebrospinal fluid of patients with febrile seizures. Recently, an association between a regulatory polymorphism in the genes encoding interleukin-1ß and interleukin-1Ra and febrile seizures was reported. In this study, we attempted to confirm these findings. We analyzed the cytokine gene polymorphisms of interleukin-1ß, interleukin-1, and interleukin-1Ra of 73 children with febrile seizure and 152 healthy controls. The distribution of interleukin-1ß —511, interleukin-1 —889, and interleukin-1Ra genotypes and alleles did not differ significantly between cases and controls. Our data suggest that the studied gene polymorphisms of interleukin-1ß, interleukin-1, and interleukin-1Ra do not have a significant role in the pathogenesis of febrile seizures. (J Child Neurol 2005;20:565—568).

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