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Journal of Child Neurology
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Aripiprazole in Children and Adolescents: Clinical Experience

Thomas A. Rugino, MD

Children's Specialized Hospital, 94 Stevens Road, Toms River, NJ 08755, trugino{at}childrens-specialized.org.

Yvette M. Janvier, MD

Children's Specialized Hospital, 94 Stevens Road, Toms River, NJ 08755,

Despite few supportive data, aripiprazole was being administered to children and adolescents for management of mood instability, aggression, and psychosis. Using a retrospective review (n = 11) and prospective recruitment (n = 6), 17 children and adolescents received aripiprazole 5 to 20 mg/day. Only 4 of 16 bipolar and autistic subjects (25%) demonstrated reduced aggression without adverse events, and the symptoms of 2 of 4 psychotic subjects improved. Coadministration of sedative medications (particularly guanfacine or clonidine) and weight < 58 kg increased the risk of adverse events, such as increased lability and aggression. All three children < 8.6 years old, all four children < 34 kg, and all five children receiving {alpha}2-agonists developed adverse events prior to clinical efficacy. Age > 11 years, weight > 58 kg, and absence of sedative medications were associated with a 56% (five of nine) success rate. Until larger, prospective studies are completed, caution is advised when considering aripiprazole for smaller children and children receiving sedative medications. (J Child Neurol 2005;20:603—610).

Journal of Child Neurology, Vol. 20, No. 7, 603-610 (2005)
DOI: 10.1177/08830738050200071301
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