This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kral, M. C. Articles by Abboud, M. R. Search for Related Content PubMed PubMed Citation Articles by Kral, M. C. Articles by Abboud, M. R. Pubmed/NCBI databases Medline Plus Health Information Sickle Cell Anemia Social Bookmarking                   What's this?

Radiographic Predictors of Neurocognitive Functioning in Pediatric Sickle Cell Disease

Department of Pediatrics, Medical University of South Carolina, Charleston, SC, kralm{at}musc.edu

Ronald T. Brown, PhD

Department of Public Health, Temple University, Philadelphia, PA

Joel K. Curé, MD

Department of Radiology, Medical University of South Carolina, Charleston, SC

Nada Besenski, MD, PhD

Department of Radiology, Medical University of South Carolina, Charleston, SC

Sherron M. Jackson, MD

Department of Pediatrics, Medical University of South Carolina, Charleston, SC

Miguel R. Abboud, MD

Department of Pediatrics, Medical University of South Carolina, Charleston, SC

We compared magnetic resonance imaging (MRI), magnetic resonance angiography, and transcranial Doppler ultrasonography as predictors of specific neurocognitive functions in children with sickle cell disease. Participants were 27 children with sickle cell anemia (hemoglobin SS) who were participants in the Stroke Prevention Trial in Sickle Cell Anemia (STOP) and had no documented history of stroke. Children's MRIs were classified as normal or silent infarct, and their magnetic resonance angiograms were classified as normal or abnormal. The highest time-averaged mean flow velocity on transcranial Doppler ultrasonographic examination of the major cerebral arteries was analyzed. Age and hematocrit also were analyzed as predictor variables. The battery of neurocognitive tests included measures of intellectual functioning, academic achievement, attention, memory, visual-motor integration, and executive functions. MRI, magnetic resonance angiography, transcranial Doppler ultrasonography, age, and hematocrit were analyzed as predictors of participants' performance on the various measures of neurocognitive functioning. Age and hematocrit were robust predictors of a number of global and specific neurocognitive functions. When age and hematocrit were controlled, transcranial Doppler ultrasonography was a significantly unique predictor of verbal memory. We found an association between low hemoglobin and neurocognitive impairment. We also found that abnormalities on transcranial Doppler ultrasonography can herald subtle neurocognitive deficits. (J Child Neurol 2006;21:37—44).

Journal of Child Neurology, Vol. 21, No. 1, 37-44 (2006)
DOI: 10.1177/08830738060210010701


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				G. R. Kirk, M. R. Haynes, S. Palasis, C. Brown, T. G. Burns, M. McCormick, and R. A. Jones Regionally Specific Cortical Thinning in Children with Sickle Cell Disease Cereb Cortex, July 1, 2009; 19(7): 1549 - 1556. [Abstract] [Full Text] [PDF]