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Giant Axonal Neuropathy: Diffusion-Weighted Imaging Features of the Brain

Department of Radiology Inonu University School of Medicineaalkan{at}inonu.edu.tr.

Ahmet Sigirci

Department of Radiology Inonu University School of Medicine

Ramazan Kutlu, MD

Department of Radiology Inonu University School of Medicine

Selim Doganay, MD

Department of Radiology Inonu University School of Medicine

Gulnur Erdem, MD

Department of Radiology Inonu University School of Medicine

Cengiz Yakinci, MD

Department of Pediatrics Inonu University School of Medicine Malatya, Turkey

Giant axonal neuropathy is a rare autosomal recessive childhood disorder characterized by a peripheral neuropathy and features of central nervous system involvement. Magnetic resonance imaging (MRI) of an 11-year-old boy with giant axonal neuropathy revealed high signal intensity in the white matter of the cerebrum and cerebellum on T₂-weighted imaging. An apparent diffusion coefficient map revealed increased apparent diffusion coefficient values in the periventricular, deep, and cerebellar white matter, basal ganglia, and thalamus. Increased apparent diffusion coefficient values in distinct locations suggest increased mobility of water molecules in the brain of a patient with giant axonal neuropathy. This finding could indicate a myelin disorder such as demyelination. Diffusion-weighted imaging should be performed to reveal apparent diffusion coefficient changes and determine brain involvement in patients with giant axonal neuropathy. (J Child Neurol 2006;21:912—915; DOI 10.2310/7010.2006.00211).

Journal of Child Neurology, Vol. 21, No. 10, 912-915 (2006)
DOI: 10.1177/08830738060210101501


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