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Journal of Child Neurology
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Coexisting Muscular Dystrophies and Epilepsy in Children

Chang-Yong Tsao, MD

Departments of Pediatrics and Neurology The Ohio State University Columbus, OH, ctsao{at}chi.osu.edu.

J.R. Mendel, MD

Departments of Pediatrics and Neurology The Ohio State University Columbus, OH, ctsao{at}chi.osu.edu.

Muscular dystrophies are composed of a variety of genetic muscle disorders linked to different chromosomes and loci and associated with different gene mutations that lead to progressive muscle atrophy and weakness. Fukuyama congenital muscular dystrophy is frequently associated with partial and generalized epilepsy and congenital brain anomalies, including cobblestone complex and other neuronal migration defects. We report generalized convulsive epilepsy in a boy with normal brain magnetic resonance imaging and Duchenne muscular dystrophy with deletion of dystrophin gene, and we report absence epilepsy with normal brain magnetic resonance imaging in another boy with limb girdle muscular dystrophy with partial calpain deficiency. We, therefore, review coexisting musclar dystrophies and epilepsy in children. In addition to Fukuyama congenital muscular dystrophy, partial or generalized epilepsy has also been reported in the following types of muscular dystrophies, including Duchenne/Becker dystrophy, facioscapulohumeral dystrophy, congenital muscular dystrophy with partial and complete deficiency of laminin {alpha} 2 (merosin) chain, and limb girdle muscular dystrophy with partial calpain deficiency. (J Child Neurol 2006;21:148—150; DOI 10.2310/7010.2006.00035).

Journal of Child Neurology, Vol. 21, No. 2, 148-150 (2006)
DOI: 10.1177/08830738060210021601
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C.-Y. Tsao and J. R. Mendell
Partial Epilepsy in an Adolescent Male With Limb-Girdle Muscular Dystrophy 1B
J Child Neurol, March 1, 2009; 24(3): 346 - 348.
[Abstract] [PDF]