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Inosiplex Affects the Spectra of Proton Magnetic Resonance Spectroscopy in Subacute Sclerosing Panencephalitis

Department of Pediatrics, Graduate School of Medicine Center for Emerging Infectious Diseases (CEID) Center for Advanced Drug Research (CADR) Gifu University, zen-k{at}cc.gifu-u.ac.jp.

Takahiko Asano, MD, PhD

Department of Radiology Graduate School of Medicine Gifu University

Naomi Kondo, MD, PhD

Department of Pediatrics, Graduate School of Medicine Center for Emerging Infectious Diseases (CEID) Center for Advanced Drug Research (CADR) Gifu University Gifu, Japan

In vivo magnetic resonance techniques such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy have been some of the most useful tools for evaluation of neurologic diseases. In subacute sclerosing panencephalitis, magnetic resonance spectroscopy can be an additional tool for evaluation of disease progression or the efficacy of the treatment, such as interferon or inosiplex, compared with MRI. Inosiplex is one of the effective drugs for subacute sclerosing panencephalitis, but our in vivo and in vitro magnetic resonance spectroscopic study indicated that inosiplex affects the spectra, suggesting a possible failure of neurologic evaluation in a patient with subacute sclerosing panencephalitis treated with inosiplex. (J Child Neurol 2006;21:177—178; DOI 10.2310/7010.2006.00048).

Journal of Child Neurology, Vol. 21, No. 2, 177-178 (2006)
DOI: 10.1177/08830738060210022101


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