This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (15) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Goldstein, E. M. Search for Related Content PubMed PubMed Citation Articles by Goldstein, E. M. Social Bookmarking                         What's this?

Safety of High-Dose Botulinum Toxin Type A Therapy for the Treatment of Pediatric Spasticity

Child Neurology Associates, Children's Healthcare of Atlanta at Scottish Rite Children's Medical Center, Marcus Institute Division of Child Neurology, Atlanta, GA, egoldstein@child

This retrospective chart review examines the safety of high-dose ( 15 U/kg body weight or 800 total units) botulinum toxin type A (BOTOX, Allergan Inc., Irvine, CA) in children and young adults with spasticity. Ninety-four children weighing < 45 kg received a mean total dose of 334.1 U or 19.1 U/kg. Fourteen young adults weighing 45 kg received a mean total dose of 927.3 U or 15.2 U/kg. Adverse events were reported by 3 of the 108 patients (2.8%) and included single instances of rash and enuresis. The only serious adverse event consisted of mild, generalized botulism in a 13-year-old patient who received a 23 U/kg dose to the hamstrings and gastrocnemius/soleus bilaterally. No serious adverse events were noted in children weighing < 45 kg who received botulinum toxin type A doses of 15 to 22 U/kg of body weight or in young adults 45 kg who received total doses of 800 to 1200 U in a single injection protocol. High-dose botulinum toxin type A is safe for the treatment of spasticity in children and young adults. (J Child Neurol 2006;21:189—192;

Journal of Child Neurology, Vol. 21, No. 3, 189-193 (2006)
DOI: 10.2310/7010.2006.00041


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. Partikian and W. G. Mitchell Iatrogenic Botulism in a Child With Spastic Quadriparesis J Child Neurol, October 1, 2007; 22(10): 1235 - 1237. [Abstract] [PDF]

				H. Namazi and S. Torabi Novel Use of Botulinum Toxin to Ameliorate Arthrofibrosis: An Experimental Study in Rabbits Toxicol Pathol, August 1, 2007; 35(5): 715 - 718. [Abstract] [Full Text] [PDF]