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Journal of Child Neurology
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Characteristic Brain Magnetic Resonance Imaging (MRI) Findings in Neonates With Tuberous Sclerosis Complex

Gemma Arca, MD

Division of Neonatal Neurology, Hospital de la Santa Creu i Sant Pau. Servicio de Pediatría, Barcelona, Spain

Esperanza Pacheco, MD

Department of Radiology, Miami Children's Hospital

Israel Alfonso, MD

Department of Neurology, Miami Children's Hospital, Miami, FL, ialfonso{at}pediatricneuro.com., Department of Neurology, University of Miami, Miami, FL

Michael S. Duchowny, MD

Department of Neurology, Miami Children's Hospital, Miami, FL, Department of Neurology, University of Miami, Miami, FL

Steven J. Melnick, MD, PhD

Department of Pathology, Miami Children's Hospital, Miami, FL

We describe the brain magnetic resonance imaging (MRI) findings in eight neonates with tuberous sclerosis complex to further delineate the spectrum of characteristic findings in these patients. In addition to the previously described characteristic brain MRI findings in neonates, which included cortical tuber, transmantle dysplasia, subependymal nodules, cerebral subependymal giant cell astrocytomas, white-matter anomalies, and hemimegalencephaly, we found one neonate with cerebellar subependymal giant cell astrocytomas and one patient who had a normal MRI and computed tomographic scan of the brain at 4 days of age but subsequently was found to have cortical tubers and subependymal nodules by MRI. (J Child Neurol 2006;21:280—285; DOI 10.2310/7010.2006.00103).

Journal of Child Neurology, Vol. 21, No. 4, 280-285 (2006)
DOI: 10.1177/08830738060210042301
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