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Corpus Callosum Size and Neuropsychologic Impairment in Adolescents who Were Born Preterm

Department of Psychiatry and Clinical Psychobiology Faculty of Medicine, University of Barcelona, Barcelona, Spain, Institut d'Investigacions Biomèdiques August Pi i Sunyer (INIBAPS) Barcelon, Spain

Ana Narberhaus, MSc

Department of Psychiatry and Clinical Psychobiology Faculty of Medicine, University of Barcelona, Barcelona, Spain

Carme Junqué, PhD

Department of Psychiatry and Clinical Psychobiology Faculty of Medicine, University of Barcelona, Barcelona, Spain, Institut d'Investigacions Biomèdiques August Pi i Sunyer (INIBAPS) Barcelon, Spain, cjunque{at}ub.edu

Mónica Giménez, MSc

Institut d'Investigacions Biomèdiques August Pi i Sunyer (INIBAPS) Barcelon, Spain

Pere Vendrell, PhD

Department of Psychiatry and Clinical Psychobiology Faculty of Medicine, University of Barcelona, Barcelona, Spain, Institut d'Investigacions Biomèdiques August Pi i Sunyer (INIBAPS) Barcelon, Spain

Núria Bargalló, MD

Neuroradiology Section Radiology Department, Centre de Diagnòstic per la Imatge (CDI), Hospital Clínic, Faculty of Medicine, University of Barcelona, Barcelona, Spain

Dolors Segarra, MD

Department of Psychiatry and Clinical Psychobiology Faculty of Medicine, University of Barcelona, Barcelona, Spain

Francesc Botet, MD

Institut d'Investigacions Biomèdiques August Pi i Sunyer (INIBAPS) Barcelon, Spain, Pediatrics Section Departments of Obstetrics and Gynecology, Pediatrics, Radiology, and Physics Medicine, Hospital Clínic, University of Barcelona, Barcelona, Spain

Prematurity is associated with cerebral abnormalities that might account for poorer cognitive performance. The aim of our study was to investigate the correlations between corpus callosum reductions and neuropsychologic performance in adolescents who were born preterm. Twenty-five subjects born before 33 weeks' gestation were compared with 25 subjects born at term and of similar age, gender, and sociocultural status. All subjects underwent magnetic resonance imaging and neuropsychologic examinations. Premature subjects performed worse than controls in global cognitive functioning, verbal memory, and verbal fluency. Corpus callosum measurements showed a global reduction owing mainly to thinning in the splenium, posterior midbody, and genu. Corpus callosum size significantly correlated with gestational age, Wechsler Performance IQ, and memory performance. These results suggest that cerebral growth during infancy does not compensate for corpus callosum reduction and that this reduction reflects neuropsychologic deficit. The cognitive impairment can arise from the paucity of the complex interneuronal connections owing to fiber damage, particularly myelinated fibers. (J Child Neurol 2006;21:406—410; DOI 10.2310/7010.2006.00106).

Journal of Child Neurology, Vol. 21, No. 5, 406-410 (2006)
DOI: 10.1177/08830738060210050801


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