This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Mittelbronn, M. Articles by Meyer-Wittkopf, M. Search for Related Content PubMed PubMed Citation Articles by Mittelbronn, M. Articles by Meyer-Wittkopf, M. Pubmed/NCBI databases Medline Plus Health Information Head and Brain Malformations Social Bookmarking                         What's this?

Coincidence of Semilobar Holoprosencephaly and Chiari II Malformation: Correlation of Prenatal Diagnostics and Neuropathologic Findings

Institute of Brain Research, University of Tuebingen Tuebingen, Germany, michel-guyandr.mittelbronn{at}med.uni-tuebingen.de

Rudi Beschorner, MD

Institute of Brain Research, University of Tuebingen Tuebingen, Germany

David Capper, MD

Institute of Brain Research, University of Tuebingen, Tuebingen, Germany

Markus Haist, MD

Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany

Richard Meyermann, MD

Institute of Brain, Research University of Tuebingen, Tuebingen, Germany

Matthias Meyer-Wittkopf, MD

Institute of Brain Research, University of Tuebingen, Tuebingen, Germany

As holoprosencephaly and Chiari II malformation differ considerably, both in pathogenesis and in phenotypic localization, the coincidence of both entities is extremely rare. The case presented is, to our knowledge, the first published report comprising a combination of a semilobar holoprosencephaly associated with a Chiari II malformation and a myelomeningocele diagnosed prenatally and confirmed by postmortem neuropathologic evaluation. These findings indicate that in the case of pre- and postnatal detection of a myelomeningocele and/or Chiari II malformation, possible additional intracranial malformation, such as a semilobar holoprosencephaly, should also be taken into account and vice versa. (J Child Neurol 2006;21:426—429; DOI 10.2310/7010.2006.00125).

Journal of Child Neurology, Vol. 21, No. 5, 426-429 (2006)
DOI: 10.1177/08830738060210051501


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?