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Journal of Child Neurology, Vol. 22, No. 1, 109-113 (2007)
DOI: 10.1177/0883073807299971

Treatment Leading to Dramatic Recovery in Acute Hemorrhagic Leukoencephalitis

Eric T. Payne, MD

Department of Pediatrics, Divisions of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

James T. Rutka, MD

Department of Neurosurgery The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Tommy K. Ho, MD

Department of Pediatric Medicine, The Hospital, for Sick Children, University of Toronto, Toronto, Ontario, Canada

William C. Halliday, MD

Department of Pediatric Laboratory Medicine, Division of Pathology The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Brenda L. Banwell, MD

Department of Pediatrics, Divisions of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada, brenda.banwell{at}sickkids.ca

The clinical course, neuroimaging, neuropathological features, and management of a 7-year-old girl with acute hemorrhagic leukoencephalitis are reported. Treatment with subtotal bifrontal craniectomies for symptoms of imminent uncal herniation followed by high-dose corticosteroid therapy was associated with dramatic clinical recovery. This report highlights the utility of aggressive intervention in acute hemorrhagic leukoencephalitis, an otherwise fatal disorder.

Key Words: acute hemorrhagic leukoencephalitis • acute disseminated encephalomyelitis • treatment


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