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Journal of Child Neurology
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Levetiracetam for the Treatment of Neonatal Seizures

Michael T. Shoemaker, MD, PhD

Department of Neonatology, Wilford Hall Medical Center, Lackland AFB, Texas

Joshua S. Rotenberg, MD

Department of Pediatric Neurology Wilford Hall Medical Center, Lackland AFB, Texas, joshua.rotenberg{at}lackland.af.mil

Seizures are a common occurrence in the neonatal intensive care unit, especially among low-birth-weight infants. The efficacy and safety of standard anticonvulsants have not been evaluated extensively in the neonate. In addition, there is concern for the adverse effects of phenobarbital on long-term development. Levetiracetam has been a commonly prescribed oral anticonvulsant for the use of adjunctive therapy for partial seizures in adults with favorable tolerability, and it has been recently approved for children older than age 4 years. There are no published studies regarding the safety and efficacy of this medication in the infant population. This report describes the initiation of levetiracetam in 3 infants, aged 2 days to 3 months, for refractory seizures or intolerance to other anticonvulsants. Each patient was without seizure on levetiracetam monotherapy, and there were no adverse effects.

Key Words: levitiracetam • neonate • seizure

Journal of Child Neurology, Vol. 22, No. 1, 95-98 (2007)
DOI: 10.1177/0883073807299973
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Home page
 J Child NeurolHome page
H. C. Glass and E. Wirrell
Controversies in Neonatal Seizure Management
J Child Neurol, May 1, 2009; 24(5): 591 - 599.
[Abstract] [PDF]