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Arterial Ischemic Stroke in Childhood: Risk Factors and Outcome in Old Versus New Era

Division of Pediatric Neurology Ege University Medical Faculty, Izmir, Turkey, stutuncu{at}med.ege.edu.tr

Ayse Tosun, MD

Department of Pediatrics Ege University Medical Faculty, Izmir, Turkey

Nuri Bayram, MD

Department of Pediatrics Ege University Medical Faculty, Izmir, Turkey

Gul Serdaroglu, MD

Division of Pediatric Neurology Ege University Medical Faculty, Izmir, Turkey

Muzaffer Polat, MD

Department of Pediatrics Ege University Medical Faculty, Izmir, Turkey

Kaan Kavakli, MD

Division of Pediatric Hematology Ege University Medical Faculty, Izmir, Turkey

Hasan Tekgul, MD

Division of Pediatric Neurology Ege University Medical Faculty, Izmir, Turkey

Risk factors of children with arterial ischemic stroke were retrospectively evaluated. The children were grouped according to values on developing diagnostic tools: 13 in the old era (1987-1994) and 18 in the new era (1995-2004). The old era battery included 5 tests: protein C, protein S, antithrombin, lupus anticoagulants, and anticardiolipin antibodies. The new era battery added 5 more tests: homocystine level, factor VIII level, mutations for factor V Leiden and prothrombin G20210A, and lipoprotein (a) level. At least 1 risk factor was found in 5 of 13 children (38.5%) in the old era and in 8 of 18 (44.4%) in the new era. The extended battery for prothrombotic disorders revealed 7 risk factors in 4 children (22.2%) in the new era, whereas the limited battery identified a single risk factor in 1 child (7.7%) in the old era. For the correct etiologic identification, prothrombotic risk factors should be extensively evaluated in patients with arterial ischemic stroke.

Key Words: childhood ischemic stroke • risk factors • outcome

Journal of Child Neurology, Vol. 22, No. 10, 1204-1208 (2007)
DOI: 10.1177/0883073807307863


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