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Journal of Child Neurology
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Iatrogenic Botulism in a Child With Spastic Quadriparesis

Arthur Partikian, MD

Pediatric Neurology Division, Childrens Hospital Los Angeles, Keck School of Medicine, and the Department of Neurology, University of Southern California, Los Angeles, apartiki{at}usc.edu

Wendy G. Mitchell, MD

Pediatric Neurology Division, Childrens Hospital Los Angeles, Keck School of Medicine, and the Department of Neurology, University of Southern California, Los Angeles

Botulinum toxins are potent neurotoxins used in a variety of neurological disorders. Few pediatric reports have been published to date regarding the potential hazards of therapeutic use of botulinum toxins. We describe the case of a 10-year-old boy who developed systemic weakness following treatment of spasticity with botulinum toxin type B. The patient developed iatrogenic botulism with ptosis, facial diplegia, neck flexor and extensor weakness, and profound hypopharyngeal laxity with respiratory compromise from which he eventually recovered. Clinicians should be mindful of the risk for systemic botulism when using local injections of the neurotoxin.

Key Words: botulism • adverse effects • spasticity • botulinum toxin

Journal of Child Neurology, Vol. 22, No. 10, 1235-1237 (2007)
DOI: 10.1177/0883073807306269
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Home page
 J Child NeurolHome page
R. M. Domingo, J. S. Haller, and M. Gruenthal
Infant Botulism: Two Recent Cases and Literature Review
J Child Neurol, November 1, 2008; 23(11): 1336 - 1346.
[Abstract] [PDF]