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Journal of Child Neurology
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*High Risk Pregnancy
*Traumatic Brain Injury
*Ulcerative Colitis
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Maternal Ulcerative Colitis and Fetal Brain Injury: Long-Term Neurologic Outcome

Mark S. Scher, MD

Rainbow Babies and Children's Hospital, Cleveland, Ohio, Mark.Scher{at}UHhospitals.org

Two maternal-fetal case presentations illustrate the possible association of active maternal ulcerative colitis during pregnancy and fetal brain injury resulting in long-term neurological sequelae. Thromboembolic complications may occur in the fetus based on similar mechanisms for stroke in children and adults with active inflammatory bowel disease. Identification of thrombophilia in the pregnant woman with active ulcerative colitis may better explain a pathophysiologic mechanism for long-term neurological morbidity in offspring.

Key Words: maternal ulcerative colitis • pregnancy • neurologic sequelae • fetal cerebrovascular disease

Journal of Child Neurology, Vol. 22, No. 11, 1293-1296 (2007)
DOI: 10.1177/0883073807307097
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