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Journal of Child Neurology, Vol. 22, No. 11, 1305-1307 (2007)
DOI: 10.1177/0883073807307087

Nephrogenic Diabetes Insipidus: A Rare Cause of Intracranial Calcification in Children

Parayil S. Bindu, DM

Departments of Neurology National Institute of Mental Health and Neurosciences, Bangalore, India, drpsbindu{at}yahoo.co.in

Jerry M. E. Kovoor, MD

Neuroimaging and Interventional Radiology National Institute of Mental Health and Neurosciences, Bangalore, India

Causes of intracranial calcification in children are numerous. This article describes an unusual cause of intracranial calcification and white matter changes in a child, namely, nephrogenic diabetes insipidus. A 4-year-old boy presented with history of polyuria, polydipsia, failure to thrive, and developmental delay. On examination, he had mild dysmorphic features and spastic paraparesis. Evaluation showed findings suggestive of nephrogenic diabetes insipidus. Computed tomography and magnetic resonance imaging revealed calcification and signal changes in the frontal and parietal subcortical white matter and gray white junction in the parietal and occipital lobes. The involvement of the white matter, in addition to the calcification in this disease, is stressed because it may predict the neurologic outcome.

Key Words: nephrogenic diabetes insipidus • intracranial calcification • white matter


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