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Journal of Child Neurology
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Rotavirus-Induced Seizures in Childhood

Marc P. DiFazio, MD

Uniformed Services University of the Health Sciences, Bethesda, mddifazio{at}aol.com

Loranee Braun, MD

Uniformed Services University of the Health Sciences, Bethesda, Walter Reed Army Medical Center, Washington, DC

Scott Freedman, MD

Shady Grove Hospital for Children, Rockville, Maryland

Patrick Hickey, MD

Uniformed Services University of the Health Sciences, Bethesda, Walter Reed Army Medical Center, Washington, DC

Rotavirus infection is a frequent cause of gastroenteritis in children and accounts for significant morbidity and mortality, especially in the developing world. Less well recognized is the association of rotavirus-induced central nervous system dysfunction, which has been associated with seizure, encephalopathy, and death. Symptoms may vary widely, however, and children can experience short afebrile convulsions as the only manifestation of rotavirus encephalopathy. We report 4 further cases of rotavirus-induced seizures with mild neurologic manifestations. The condition is reviewed and practical management strategies are suggested.

Key Words: rotavirus • seizure • encephalopathy • virus • epilepsy

Journal of Child Neurology, Vol. 22, No. 12, 1367-1370 (2007)
DOI: 10.1177/0883073807307083
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