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Journal of Child Neurology, Vol. 22, No. 2, 135-142 (2007)
DOI: 10.1177/0883073807300295

Does Albendazole Affect Seizure Remission and Computed Tomography Response in Children With Neurocysticercosis? A Systematic Review and Meta-analysis

Maitreyi Mazumdar, MD, MPH

Department of Neurology, Children's Hospital Boston, Boston, Massachusetts, maitreyi.mazumdar{at}childrens.harvard.edu

Pari Pandharipande, MD

Institute for Technology Assessment, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts

Annapurna Poduri, MD

Department of Neurology, Children's Hospital Boston, Boston, Massachusetts

A recent trial suggested that albendazole reduces seizures in adults with neurocysticercosis. There is still no consensus regarding optimal management of neurocysticercosis in children. The authors conducted a systematic review and meta-analysis to assess the efficacy of albendazole in children with neurocysticercosis, by searching the Cochrane Databases, MEDLINE, EMBASE, and LILACS. Three reviewers extracted data using an intent-to-treat analysis. Random effects models were used to estimate relative risks. Four randomized trials were selected for meta-analysis, and 10 observational studies were selected for qualitative review. The relative risk of seizure remission in treatment versus control was 1.26 (1.09, 1.46). The relative risk of improvement in computed tomography in these trials was 1.15 (0.97, 1.36). Review of observational studies showed conflicting results, likely owing to preferential administration of albendazole to sicker children.

Key Words: neurocysticercosis • drug therapy • epilepsy


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