Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for FREE ACCESS to this landmark database

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Bindu, P.S.
Right arrow Articles by Shetty, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bindu, P.S.
Right arrow Articles by Shetty, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Extensive Cortical Magnetic Resonance Signal Change in Proximal Urea Cycle Disorder

P.S. Bindu, MD, DM

Department of Neurology, National Institute of Mental Health and NeuroSciences, Bangalore, India

S. Sinha, MD, DM

Department of Neurology, National Institute of Mental Health and NeuroSciences, Bangalore, India, sanjib_sinha{at}nimhans.kar.nic.in

A.B. Taly, MD, DM

Department of Neurology, National Institute of Mental Health and NeuroSciences, Bangalore, India

H.S. Chandrasekhar, MD

Department of Neuroradiology, National Institute of Mental Health and NeuroSciences, Bangalore, India

R. Christopher, MD

Department of Neurochemistry, National Institute of Mental Health and NeuroSciences, Bangalore, India

G.R. Arunodaya, DM

Department of Neurology, National Institute of Mental Health and NeuroSciences, Bangalore, India

T. Shetty, PhD

Department of Neurochemistry, National Institute of Mental Health and NeuroSciences, Bangalore, India

The authors report a 3-year 8-month-old girl presenting with episodic hyperammonemic encephalopathy probably due to a proximal urea cycle disorder. The magnetic resonance imaging (MRI) of the brain performed during the third episode revealed extensive and diffuse cerebral cortical signal changes with sparing of occipital cortex. It is believed that intracerebral accumulation of glutamine mainly in astrocytes is the major cause of the encephalopathy. This results in astrocyte swelling, brain edema, intracranial hypertension, and cerebral hypoperfusion.

Key Words: urea cycle disorder

Journal of Child Neurology, Vol. 22, No. 2, 238-239 (2007)
DOI: 10.1177/0883073807300308
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?