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Postterm Closure of the Cavum Septi Pellucidi and Developmental Outcome in Premature Infants

Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, hneedelm{at}unmc.edu

Bruce Schroeder, MD

Department of Radiology, Children's Hospital, Omaha, Nebraska

Matthew Sweeney, MD

Department of Pediatrics, University of Nebraska Medical Center, Omaha

John Schmidt, MD

Department of Pediatrics, University of Nebraska Medical Center, Omaha

John B. Bodensteiner, MD

Pediatric Neurology, Barrow's Neurologic Institute, St Joseph Hospital, Phoenix, Arizona

G.B. Schaefer, MD

Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha

The authors report the natural history of closure of the cavum Septi pellucidi in premature infants 26 to 27 weeks postconception at birth and compare the developmental outcome in these infants who had closure by 42 weeks postconception to those who still had a cavum septum pellucidi visualized on ultrasound at approximately term (35-42 weeks). Of 72 patients, 35 patients still had a cavum septum pellucidi visualized on the last ultrasound done between 35 and 42 weeks postconception, and the developmental outcome of these patients was no different from those with earlier closure. The authors conclude that persistence of a cavum septi pellucidi through term is not an independent risk factor for developmental delay.

Key Words: brain development • midline brain anomalies • developmental outcome • Septum Pellucidum

Journal of Child Neurology, Vol. 22, No. 3, 314-316 (2007)
DOI: 10.1177/0883073807300538


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