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Journal of Child Neurology
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*Infectious Mononucleosis
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Acute Disseminated Encephalomyelitis Following Infectious Mononucleosis

Hamid R. Bahadori, MD

Medical University of South Carolina, Charleston, bahadori{at}musc.edu

Virginia C. Williams, BS

Medical University of South Carolina, Charleston

Robert P. Turner, MD, MSCR

Medical University of South Carolina, Charleston

Zoran Rumboldt, MD

Medical University of South Carolina, Charleston

J. Routt Reigart, MD

Medical University of South Carolina, Charleston

Sandra L. Fowler, MD, MSc

Medical University of South Carolina, Charleston

Pamela S. Chavis, MD

Medical University of South Carolina, Charleston

Bernard L. Maria, MD, MBA

Medical University of South Carolina, Charleston

Two months following an Epstein-Barr virus infection, a 17-year-old white female presented with seizures, intermittent visual changes, and altered mental status. Magnetic resonance imaging showed white matter changes of acute disseminated encephalomyelitis with a predilection for posterior cerebral artery distributions but without radiological evidence of arteritis. Epstein-Barr virus titers and polymerase chain reaction analysis results for the virus were consistent with postinfectious acute disseminated encephalomyelitis. The symptoms and signs improved following treatment with high-dose corticosteroids and intravenous immunoglobulin. Although Epstein-Barr virus can cause acute viral encephalomyelitis, the authors report a case of acute disseminated encephalomyelitis months after acute Epstein-Barr virus infection.

Key Words: acute disseminated encephalomyelitis • Epstein-Barr virus • mononucleosis

Journal of Child Neurology, Vol. 22, No. 3, 324-328 (2007)
DOI: 10.1177/0883073807300534
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