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Serum Retinol and ß-Carotene Levels in Subacute Sclerosing Panencephalitis

Department of Pediatric Neurology, Inönü University Faculty of Medicine, Malatya, Turkey

Akgun Olmez, MD

Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Pinar Arikan Firat, MD

Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Goknur Halilolu, MD

Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Banu Anlar, MD

Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey, banlar{at}hacettepe.edu.tr

Reduced serum levels of vitamin A affect morbidity and mortality in measles. The authors' newly diagnosed subacute sclerosing panencephalitis (n = 21) and age-matched control groups (n = 20) had mean serum ß-carotene levels of 1.12 ± 0.56 and 1.50 ± 0.52 µg/mL, respectively. Serum retinol <20 µg/dL was observed in 6 of 21 subacute sclerosing panencephalitis and 0 of 20 control cases (P < .05). Vitamin A deficiency can accompany subacute sclerosing panencephalitis: its contribution to the pathogenesis or course of the disease warrants further investigations.

Key Words: subacute sclerosing panencephalitis • vitamin A • measles

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