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Journal of Child Neurology
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Reviews

Extended-Release Formulations in Epilepsy

Alberto Verrotti, MD, PhD

Department of Medicine, Section of Pediatrics, University of Chieti, Italy, averrott{at}unich.it

Carmela Salladini, MD

Department of Medicine, Section of Pediatrics, University of Chieti, Italy

Giovanna Di Marco, MD

Department of Medicine, Section of Pediatrics, University of Chieti, Italy

Floriana Pisciella, MD

Department of Medicine, Section of Pediatrics, University of Chieti, Italy

Francesco Chiarelli, PhD, MD

Department of Medicine, Section of Pediatrics, University of Chieti, Italy

In the past years, the extended-release antiepileptic drug formulations have been developed and then approved for the treatment of many types of epilepsy. Among these extended-release formulations of antiepileptic drugs, the main drugs are valproic acid, carbamazepine, and phenytoin. This review analyzes the chemical and structural characteristics of the extended-release formulations of these 3 antiepileptic drugs, analyzing their bioequivalence and the studies about their clinical use. The results of these studies are encouraging and suggest a good tolerability and efficacy of these extended-release formulations, although larger studies are needed.

Key Words: antiepileptic drugs • extended release • compliance • valproate • carbamazepine • phenytoin

Journal of Child Neurology, Vol. 22, No. 4, 419-426 (2007)
DOI: 10.1177/0883073807302760
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