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Journal of Child Neurology
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Acute Ophthalmoparesis Associated With Anti-GM1, Anti-GD1a, and Anti-GD1b Antibodies After Enterovirus Infection in a 6-Year-Old Girl

Carlo Fusco, MD

Child Neurology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy, Fusco.Carlo{at}asmn.re.it

Gianna Bertani, MD

Child Neurology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

Angela Scarano, MD

Child Neurology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

Elvio Della Giustina, MD

Child Neurology Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

This article presents a 6-year-old girl who developed acute unilateral third cranial nerve palsy in the absence of any other sign of central nervous system involvement. Raised titers of immunoglobulin M antibodies against GM1, GD1a, and GD1b ganglioside components were demonstrated. Ten days earlier, the girl had experienced acute gastroenteritis with positive specific immunoglobulin M antibodies against enterovirus. The results of all other laboratory tests usually performed for infectious diseases were negative, and neuroradiologic findings were also normal. Oral prednisone was administered for a few days, and the ophthalmoparesis fully resolved within 1 month. Two months later, a second episode of isolated ophthalmoparesis occurred, again associated with a positive immunoglobulin M reaction against GM1, GD1a, and GD1b antigens. This report discusses the relationship between acute isolated ophthalmoparesis and antiganglioside antibodies.

Key Words: antiganglioside antibodies • ophthalmoparesis • GM1 • GD1a • GD1b

Journal of Child Neurology, Vol. 22, No. 4, 432-434 (2007)
DOI: 10.1177/0883073807301921
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