Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Russo, R.
Right arrow Articles by Fallet-Bianco, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Russo, R.
Right arrow Articles by Fallet-Bianco, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Isolated Posterior Cerebellar Vermal Defect: A Morphological Study of Midsagittal Cerebellar Vermis in 4 Fetuses—Early Stage of Dandy-Walker Continuum or New Vermal Dysgenesis?

Rosa Russo, MD

Department of Pathology, Hospital S. Giovanni di Dio, e Ruggi d'Aragona, Salerno, Italy, russorosa{at}yahoo.it

Catherine Fallet-Bianco, MD

Department of Pathology, Hospital Sainte-Anne, Paris, France

This report is a neuropathological description of posterior cerebellar vermis agenesis/hypoplasia at midgestation. This defect was demonstrated by prenatal ultrasound in four 21- to 24-week-old fetuses. Neuropathological findings were characterized macroscopically by hypoplasia of the posterior vermis with normal cerebellar hemispheres and brainstem; hypoplasia of the posterior vermian lobules 6 to 10, mildly cystic dilatation of the ventricular cavity, and a flat profile of the roof of the fourth ventricle also were demonstrated. Microscopically, a hypercellular and abnormally located germinal matrix and abnormal migration of external granule cell precursors into the meningeal tissue above the outer surface of the cerebellum were found. These abnormalities might result in delayed growth and foliation of the posterior vermian lobules. This feature might be the neuropathological pattern of the early stage of the Dandy-Walker continuum, although it cannot be excluded as a consequence of a primary developmental failure of the vermal primordium.

Key Words: cerebellar vermis • cerebellum • Dandy-Walker variant • hypoplasia • neuropathology

Journal of Child Neurology, Vol. 22, No. 4, 492-500 (2007)
DOI: 10.1177/0883073807299862
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?