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Journal of Child Neurology
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Familial Risk Factors in Autism

Michael Brimacombe, PhD

Department of Preventive Medicine, New Jersey Medical School University of Medicine and Dentistry of New Jersey, Newark, brimacmb{at}umdnj.edu

Xue Ming, MD, PhD

Department of Neurology, New Jersey Medical School-University of Medicine and Dentistry of New Jersey, Newark

Amisha Parikh, MPH

Department of Preventive Medicine, New Jersey Medical School University of Medicine and Dentistry of New Jersey, Newark

Familial history risk factors in relation to autism were examined in a cohort of 164 autistic children referred to The Autism Center at New Jersey Medical School—University of Medicine and Dentistry of New Jersey, Newark, over a 2-year period (2001-2003). Information related to familial history was obtained from each family and reviewed by a clinician. It is shown that these families carry a higher overall burden of psychiatric and developmental illnesses compared to reported national levels. These families also carry a relatively high incidence of medical disorders, independently of developmental and psychiatric disorders. This work supports the underlying presence of genetic factors in the etiology of autism.

Key Words: autism • family history • psychiatric disorders • developmental disorders • epidemiology

Journal of Child Neurology, Vol. 22, No. 5, 593-597 (2007)
DOI: 10.1177/0883073807302609
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