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Journal of Child Neurology
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Persistence of Suppression-Bursts in a Patient With Ohtahara Syndrome

Russell P. Saneto, DO, PhD

Division of Pediatric Neurology, Children's Hospital and Regional Medical Center/University of Washington, Seattle, Washington, russ.saneto{at}seattlechildrens.org

Marcio Sotero de Menezes, MD

Division of Pediatric Neurology, Children's Hospital and Regional Medical Center/University of Washington, Seattle, Washington

Early infantile epileptic encephalopathy, or Ohtahara syndrome, is characterized by tonic spasms and a suppression-burst pattern on the electroencephalography (EEG). The EEG demonstrates a suppression-burst pattern during waking and sleeping states that often evolves into hypsarrhythmia and followed later by a diffuse slow spike-wave pattern. In other patients, the EEG evolves into focal spike discharges or multiple independent spike foci. We report a 5-year-old girl with Ohtahara syndrome that persistently demonstrated tonic spasms and suppression-burst on multiple EEGs. Over her lifetime, neither hypsarrhythmia nor diffuse slow spike-wave pattern were seen. This suggests that in Ohtahara syndrome, a suppression-burst pattern can persist over a long period of time.

Key Words: Ohtahara syndrome • suppression-burst pattern • early infantile epileptic encephalopathy

Journal of Child Neurology, Vol. 22, No. 5, 631-634 (2007)
DOI: 10.1177/0883073807303220
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