Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Perniola, T.
Right arrow Articles by Carella, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perniola, T.
Right arrow Articles by Carella, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Costello Syndrome: Cognitive and Proton Magnetic Resonance Spectroscopy Findings—A Case Report

Tommaso Perniola, MD

Department of Neurologic and Psychiatry Sciences, Child Neuropsychiatric Service, University of Bari, Italy

Franca Dicuonzo, MD

Department of Neurologic and Psychiatry Sciences, Neuroradiologic Service University of Bari, Italy

Lucia Margari, MD

Department of Neurologic and Psychiatry Sciences, Child Neuropsychiatric Service, University of Bari, Italy, l.margari@neurol .uniba.it

Anna Presicci, MD

Department of Neurologic and Psychiatry Sciences, Child Neuropsychiatric Service, University of Bari, Italy

Patrizia Ventura, MD

Department of Neurologic and Psychiatry Sciences, Child Neuropsychiatric Service, University of Bari, Italy

Michele Palma, MD

Department of Neurologic and Psychiatry Sciences, Neuroradiologic Service University of Bari, Italy

Aristide Carella, MD

Department of Neurologic and Psychiatry Sciences, Neuroradiologic Service University of Bari, Italy

The authors describe a girl with Costello syndrome who showed cerebral palsy and neurosensorial deafness. Brain computer tomography and magnetic resonance findings were normal. Multivoxel proton magnetic resonance spectroscopy showed a lowering of the peak of choline with a reduced choline/creatine ratio at the level of the centrum semiovale. These findings might be due to a congenital dysmyelinating or hypomyelinating condition. A complete neuroimaging study can play a relevant role to better clarify the pathogenesis of brain involvement in Costello syndrome.

Key Words: Costello syndrome • proton magnetic resonance • choline

Journal of Child Neurology, Vol. 22, No. 5, 650-654 (2007)
DOI: 10.1177/0883073807302615
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?