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Journal of Child Neurology, Vol. 22, No. 7, 812-817 (2007)
DOI: 10.1177/0883073807304197
© 2007 SAGE Publications

Methylphenidate-Induced Changes in Cerebral Hemodynamics Measured by Functional Near-Infrared Spectroscopy

Peter Weber, MD

Department of Neuropediatrics, University Children's Hospital Basel, Switzerland, peter.weber{at}unibas.ch

Jürg Lütschg, MD

Department of Neuropediatrics, University Children's Hospital Basel, Switzerland

Hubert Fahnenstich, MD

Children's Hospital Lörrach, Germany

The aim of the present preliminary study was to evaluate the feasibility of measuring cerebral hemodynamic effects of a clinical dose of methylphenidate by near-infrared spectroscopy in 10 boys (median age, 10.7 years; range, 8.6-11.8 years) with developmental attention-deficit/hyperactivity disorder (ADHD). Using a Trail Making Test known to activate the left dorsolateral prefrontal cortex, cerebral hemodynamic changes show a lower increase of cerebral blood volume in the right prefrontal cortex (P = .033) and a lower increase of the tissue oxygenation index in the left prefrontal cortex (P = .015) in the condition after intake of methylphenidate compared with a drug-naive situation. A lower increase of the tissue oxygenation index indicates a changing regional oxygen metabolism and consumption induced by methylphenidate. Near-infrared spectroscopy is a sensitive tool for measuring pharmacological effects of methylphenidate on the cerebral hemodynamics.

Key Words: methylphenidate • attention-deficit/hyperactivity disorder (ADHD) • functional near-infrared spectroscopy


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