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Journal of Child Neurology
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Amplitude-Integrated EEG Is Useful in Predicting Neurodevelopmental Outcome in Full-Term Infants With Hypoxic-Ischemic Encephalopathy: A Meta-Analysis

R. Edwin Spitzmiller, DO

Department of Pediatrics, Divisions of Neonatology, University of Cincinnati and the Cincinnati Children's Hospital Medical Center, Cincinnati, OH, Edwin_Spitzmiller{at}pediatrix.com

Tonya Phillips, MD

Division of Neurology

Jareen Meinzen-Derr, PhD

Division of Epidemiology and Biostatistics

Steven B. Hoath, MD

Department of Pediatrics, Divisions of Neonatology, University of Cincinnati and the Cincinnati Children's Hospital Medical Center, Cincinnati, OH, Division of Skin Sciences Institute, University of Cincinnati and the Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Hypoxic ischemic encephalopathy is a common cause of neurological complications resulting in chronic handicapping conditions, such as cerebral palsy. Amplitude-integrated electroencephalography (EEG) has been used in many European countries for more than a decade in the evaluation of infants with hypoxic ischemic encephalopathy but has not been widely used in the United States. The objective of this study was to evaluate the evidence supporting use of amplitude-integrated EEG as a quantitative predictor of neurodevelopmental outcome in full-term infants with hypoxic ischemic encephalopathy. To assess efficacy, the authors performed a meta-analysis of the literature evaluating the use of the amplitude-integrated EEG or cerebral function monitor in full-term infants with hypoxic ischemic encephalopathy and their neurodevelopmental outcome. A total of 8 studies were eligible for the primary meta-analysis. There was an overall sensitivity of 91% (95% CI 87-95) and a negative likelihood ratio of 0.09 (95% CI .06-.15) for amplitude-integrated EEG tracings to accurately predict poor outcome. Amplitude-integrated EEG is a valuable bedside tool for predicting long-term neurodevelopmental outcome in term infants with hypoxic ischemic encephalopathy. This information is useful in structuring communication and care plans for physicians and parents. Early assessment techniques such as amplitude-integrated EEG provide objective means for determining inclusion in clinical studies evaluating therapies for hypoxic ischemic encephalopathy and for predicting which patients are most likely to respond to treatment.

Key Words: amplitude-integrated EEG • full-term newborn • hypoxic ischemic encephalopathy • meta-analysis

Journal of Child Neurology, Vol. 22, No. 9, 1069-1078 (2007)
DOI: 10.1177/0883073807306258
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