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Journal of Child Neurology
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0883073807307986v1
23/1/106    most recent
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Juvenile Onset Central Nervous System Folate Deficiency and Rheumatoid Arthritis

Mary Kay Koenig, MD

University of Texas Medical School at Houston

Maria Perez, MD

Baylor College of Medicine, Houston, Texas

Sheldon Rothenberg, MD

State University of New York Downstate Medical Center, Brooklyn

Ian J. Butler, MB, BS, FRACP

University of Texas Medical School at Houston, ian.j.butler{at}uth.tmc.edu

Isolated cerebral folate deficiency was detected in a 13-year-old girl with cognitive and motor difficulties and juvenile rheumatoid arthritis. Her serum contains autoantibodies that block membrane-bound folate receptors that are on the choroid plexus and diminish the uptake of folate into the spinal fluid. Whereas her serum folate exceeded 21 ng/mL, her spinal fluid contained 3.2 ng/mL of 5-methyltetrahydrofolate as a consequence of the autoantibodies diminishing the uptake of this folate.

Key Words: folate • rheumatoid • autoantibody

This version was published on January 1, 2008

Journal of Child Neurology, Vol. 23, No. 1, 106-107 (2008)
DOI: 10.1177/0883073807307986
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