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Tumors of the Central Nervous System: Clinical Aspects, Molecular Mechanisms, Unanswered Questions, and Future Research Directions

College of Medicine, Medical University of South Carolina, Charleston, South Carolina

Felina V. Kostova, BS

College of Medicine, Medical University of South Carolina, Charleston, South Carolina

Abhijit Guha, MD

Arthur and Sonia Labatts Brain Tumor Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Roger J. Packer, MD

Center of Excellence for Neuroscience and Behavioral Medicine, Division of Child Neurology, Children's National Medical Center, Washington, DC

Ian F. Pollack, MD

Department of Neurosurgery, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Bernard L. Maria, MD, MBA

Departments of Pediatrics and Neurosciences, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, Charleston, South Carolinamariabl{at}musc.edu

Central nervous system tumors are the most common solid tumors in children. Many histological subtypes and biological variants exist. The 2007 Neurobiology of Disease in Children Symposium, held in conjunction with the 36th annual meeting of the Child Neurology Society, aimed to define current knowledge in the field and to develop specific aims for future clinical, translational, and fundamental science. Because of advances in structural and metabolic imaging, surgical technique, and combination therapies, the life expectancy of children with some of the most common tumors, such as cerebellar astrocytomas and medulloblastomas, has improved. Other common tumor types, including diffuse pontine gliomas and malignant embryonal tumors, still have a dismal prognosis. As novel therapies are identified for pediatric central nervous system tumors, long-term survival may be associated with considerable disability. A cooperative effort is crucial to early diagnosis and to translating basic research findings into safe, effective new treatments.

Key Words: pediatric brain tumors • molecular mechanisms • translational research

Journal of Child Neurology, Vol. 23, No. 10, 1103-1121 (2008)
DOI: 10.1177/0883073808321767


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