| Sign In to gain access to subscriptions and/or personal tools. |
Aggressive Infantile Embryonal TumorsDivision of Oncology, Center for Cancer and Blood Disorders, Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, Washington, DC, The George Washington University School of Medicine and Health Sciences, Washington, DC, tmacdona{at}cnmc.org Embryonal tumors are the most common brain tumors in infants less than 36 months. Histologically characterized as undifferentiated small, round cell tumors with divergent patterns of differentiation, these include medulloblastoma, the most common form of embryonal tumor, as well as supratentorial primitive neuroectodermal tumor, medulloepithelioma, ependymoblastoma, medullomyoblastoma, melanotic medulloblastoma, and atypical teratoid/rhabdoid tumor. All are similarly aggressive and have a tendency to disseminate throughout the central nervous system. Because of efforts to avoid craniospinal irradiation in an attempt to lessen treatment-related neurotoxicity, management of these tumors in infants is unique. Outcomes remain similarly poor among all the tumor types and, therefore, identification of specific molecular targets that have prognostic and therapeutic implications is crucial. The molecular and clinical aspects of the 3 most common aggressive infantile embryonal tumors, medulloblastoma, supratentorial primitive neuroectodermal tumor, and atypical teratoid/rhabdoid tumor, are the focus of this review.
Key Words: infant • embryonal • brain tumor
Journal of Child Neurology, Vol. 23, No. 10,
1195-1204 (2008) This article has been cited by other articles:
|
|||||||||||||||
 |
|
|
 |
Sign In to gain access to subscriptions and/or personal tools.
