Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Maria, B. L.
Right arrow Articles by Toole, B. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maria, B. L.
Right arrow Articles by Toole, B. P.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Targeting Hyaluronan Interactions in Spinal Cord Astrocytomas and Diffuse Pontine Gliomas

Bernard L. Maria, MD, MBA

Departments of Pediatrics and Neurosciences, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, mariabl{at}musc.edu

Nalin Gupta, MD, PhD

Department of Neurosurgery, University of California, San Francisco

Anne G. Gilg, PhD

Department of Pediatrics, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, Charleston, South Carolina

May Abdel-Wahab, MD

Department of Radiation Oncology, University of Miami

Anthony P. Leonard, BS

College of Medicine, Medical University of South Carolina, Charleston, South Carolina

Mark Slomiany, PhD

Department of Cell Biology and Anatomy, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, Charleston, South Carolina

William G. Wheeler, BS

Department of Pediatrics, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, Charleston, South Carolina

Lauren B. Tolliver, MS

Department of Pediatrics, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, Charleston, South Carolina

Michael A. Babcock, BS

College of Medicine, Medical University of South Carolina, Charleston, South Carolina

John T. Lucas, Jr, BS

College of Medicine, Medical University of South Carolina, Charleston, South Carolina

Bryan P. Toole, PhD

Department of Cell Biology and Anatomy, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, Charleston, South Carolina

Although significant advances have been made in treating malignant pediatric central nervous system tumors such as medulloblastoma, no effective therapy exists for diffuse pontine glioma or intramedullary spinal astrocytoma. Biology of these 2 tumors is poorly understood, in part because diffuse pontine gliomas are not treated surgically, and tumor specimens from intramedullary spinal astrocytomas are rare and minuscule. At the 2007 Neurobiology of Disease in Children Symposium, we presented evidence that malignant glioma behaviors, including antiapoptosis, invasiveness, and treatment resistance, are enhanced by hyaluronan, an extracellular glycosaminoglycan. We review the clinical course of pediatric intramedullary spinal astrocytoma and diffuse pontine glioma, and show expression of membrane proteins that interact with hyaluronan: CD44, extracellular matrix metalloproteinase inducer, and breast cancer resistance protein (BCRP/ABCG2). Furthermore, we describe novel animal models of these tumors for preclinical studies. These findings suggest that hyaluronan antagonism has potential therapeutic value in malignant central nervous system tumors.

Key Words: hyaluronan • glioma • astrocytoma

Journal of Child Neurology, Vol. 23, No. 10, 1214-1220 (2008)
DOI: 10.1177/0883073808321771
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J Child NeurolHome page
R. A. Brumback
Child Neurologists Should Be Interested In Brain Tumors!
J Child Neurol, November 1, 2009; 24(11): 1338 - 1340.
[PDF]