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Journal of Child Neurology
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Possible Pathogenic Link Between Migraine and Urotensin-II

Ugur Bicak, MD

Department of Pediatrics, Inonu University Medical School at Malatya

Hamza Karabiber, MD

Department of Pediatrics, Kahramanmaras Sutcu Imam University Medical School at Kahramanmaras, hkarabiber{at}hotmail.com

Halil I. Ozerol, MD

Department of Microbiology, Inonu University Medical School at Malatya

Mehmet Aslan, MD

Department of Pediatrics, Inonu University Medical School at Malatya

Atilla Ilhan, MD

Department of Neurology, Fatih University Medical School at Ankara Turkey

Cengiz Yakinci, MD

Department of Pediatrics, Inonu University Medical School at Malatya

Our aim was to determine the levels of human urotensin-II (hU-II) in the plasma of migraine patients and controls, to ascertain if there were a difference in the pathogenesis of migraine. A total of 27 patients who suffer from migraines and 27 controls were included in the study. Venous blood samples were drawn twice both from migraine patients and controls to measure hU-II plasma levels. The average levels of hU-II during migraine episode, between episodes, and controls were found to be 0.483, 0.493, and 0.737 pg/mL, respectively. The levels of hU-II in the controls were higher significantly. When comparisons were made according to sex, age groups, and types and durations of migraine, there was no significant difference in the levels of hU-II in the patients. The low levels of hU-II in the plasma of migraine patients compared with controls may be an indicator of its role in the pathogenesis.

Key Words: etiopathogenesis • migraine • urotensin II

Journal of Child Neurology, Vol. 23, No. 11, 1249-1253 (2008)
DOI: 10.1177/0883073808318052
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