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Neuropsychological, Behavioral, and Adaptive Functioning of Swiss Children With Congenital Central Hypoventilation Syndrome

Division of Neuropediatrics, University Children's Hospital Basel

Juerg Hammer, MD

Division of Pulmonology and Intensive Care, University Children's Hospital Basel

Bettina Tillmann, MD

Division of Neuropediatrics, University Children's Hospital Basel

Daniela Ghelfi, MD

Division of Intensive Care, University Children's Hospital Zurich, Switzerland

Peter Weber, MD

Division of Neuropediatrics, University Children's Hospital Basel, peter.weber{at}unibas.ch

This study collected data about developmental problems in a cohort of children with congenital central hypoventilation syndrome. In 2003, in Switzerland, 11 children with this disease were registered. Nine of them gave their informed consent to participate in the study and were examined. Clinical assessments were conducted, including examinations of neuropsychological, behavioral, and adaptive functions using Kaufman-Assessment Battery for Children, Child Behavior Checklist, and Vineland Adaptive Behavior Scales. The mean age (± standard deviation) was 7.5 ± 2.5 years. The cognitive tests showed problems in working memory functions with a near-to-normal full-range intelligence quotient (87.4 ± 23.3). The children showed normal values (t-values < 67) on problem scales of behavior, although 5 of the 9 children showed elevated values on the attention and on the social interaction problem scales. Adaptive function problems were identified in communication and daily living skills.

Key Words: congenital central hypoventilation syndrome • developmental functioning

Journal of Child Neurology, Vol. 23, No. 11, 1254-1259 (2008)
DOI: 10.1177/0883073808318048


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