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Effect of Acupuncture on the Brain in Children With Spastic Cerebral Palsy Using Functional Neuroimaging (fMRI)

Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing

Zhen Jin, MD, PhD

Center for fMRI & Department of Radiology, No. 306 Hospital of PLA, Beijing

Ke Li, MD

Center for fMRI & Department of Radiology, No. 306 Hospital of PLA, Beijing

Zhong-Li Lu, MD

Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing

Virginia Wong, MD, PhD

Division of Neurodevelopmental Paediatrics, Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, China

Tong-Li Han, MD

Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing

Hua Zheng, MD

Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing

Opher Caspi, MD, PhD

The Recanati Center for Medicine and Research, and the Section of Integrative Medicine, Rabin Medical Center (Beilinson Campus), and the Tel-Aviv Sourasky Faculty of Medicine, Israel

Gang Liu, MD

Center for fMRI & Department of Radiology, No. 306 Hospital of PLA, Beijing

Ya-Wei Zeng, MD

Center for fMRI & Department of Radiology, No. 306 Hospital of PLA, Beijing

Li-Ping Zou, MD, PhD

Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing, and , Department of Pediatrics, Chinese PLA General Hospital (No. 301 Hospital of PLA), Beijing, China, zouliping21{at}hotmail.com

We study the effect of acupuncture on brain activation patterns in children with cerebral palsy using functional magnetic resonance imaging (fMRI). fMRI of the whole brain was performed in 11 children with cerebral palsy and 10 healthy children during stimulation of a common acupoint in Traditional Medicine [Liv3 (Taichong)] on the left foot. We use both twisting and nontwisting methods with a blocked paradigm on a 2.0 Tesla MRI scanner. Functional data were analyzed by using Statistical Parametric Mapping software (SPM 99). Both signal increase and decrease in various regions of the brain were found in both groups of children. However, the pattern was different for the 2 groups, especially with decreases in signal regions. We suggest that the observed differences between children with cerebral palsy and healthy children with the stimulation of acupoint Liv3 might be due to blockage of the liver meridian in children with cerebral palsy.

Key Words: acupuncture • functional magnetic resonance imaging (fMRI) • cerebral palsy

Journal of Child Neurology, Vol. 23, No. 11, 1267-1274 (2008)
DOI: 10.1177/0883073808318049


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