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Long-Term Outcome of Symptomatic Infantile Spasms Established by Video-Electroencephalography (EEG) Monitoring

Comprehensive Epilepsy Center, Department of Neurology, Columbia University College of Physician & Surgeons, New York, New York

Karen Eck, RN, NP

Comprehensive Epilepsy Center, Department of Neurology, Columbia University College of Physician & Surgeons, New York, New York

Susan Jacob, RN, NP

Comprehensive Epilepsy Center, Department of Neurology, Columbia University College of Physician & Surgeons, New York, New York

Joshua Cappell, MD, PhD

Comprehensive Epilepsy Center, and Division of Pediatric Neurology, Department of Neurology, Columbia University College of Physician & Surgeons, New York, New York

Claudia Chriboga, MD, MPH

Division of Pediatric Neurology, Department of Neurology, Columbia University College of Physician & Surgeons New York, New York

Ronald Emerson, MD

Comprehensive Epilepsy Center, Department of Neurology, Columbia University College of Physician & Surgeons, New York, New York

Marc C. Patterson, MD

Division of Pediatric Neurology, Department of Neurology, Columbia University College of Physician & Surgeons New York, New York

Cigdem I. Akman, MD

Comprehensive Epilepsy Center, and Division of Pediatric Neurology, Department of Neurology, Columbia University College of Physician & Surgeons, New York, New York, cia11{at}columbia.edu

In this study, we examine the long-term clinical outcome of children with symptomatic infantile spasm. The children between 2 and 18 years of age diagnosed with symptomatic infantile spasms were reviewed. Sixty-eight children (age range, 2-13 years; mean, 4.5 years) met the inclusion criteria. Children who underwent epilepsy surgery were excluded. Age of onset for infantile spasms ranged from 1 to 24 months (mean, 7.1 months). Developmental delay was noted in all; there was seizure freedom in 14 children (20.5%). Infantile spasms were reported as the only seizure type in 10 (14.5%) children older than age 2 years. During the follow-up; symptomatic generalized epilepsy was diagnosed in 23 childern (34%) and focal epilepsy in 21 (31%). The long-term outcome of these children remains unchanged in the majority of the children with symptomatic infantile spasms. We could not establish any risk factor that might be related to favorable or adverse outcome.

Key Words: symptomatic infantile spasms • epilepsy • video-electroencephalography (EEG) monitoring

Journal of Child Neurology, Vol. 23, No. 11, 1288-1292 (2008)
DOI: 10.1177/0883073808318540


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