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Journal of Child Neurology
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Late Relapse of Herpes Simplex Virus Encephalitis in a Child Due to Reactivation of Latent Virus: Clinicopathological Report and Review

Ronen Spiegel, MD

Pediatric Department A, Ha Emek Medical Center, spiegelr{at}zahav.net.il, spiegel_ro{at}clalit.org.il, Rappaport School of Medicine Technion, Haifa, Israel

Dan Miron, MD

Pediatric Department A, Ha Emek Medical Center, Rappaport School of Medicine Technion, Haifa, Israel

Helena Yodko, MD

Pathology Department, Ha Emek Medical Center

Dmitry Lumelsky, MD

Radiology Department, Ha Emek Medical Center, Afula, Israel

Adib Habib, MD

Pediatric Department French Hospital, Nazareth, Israel

Yoseph Horovitz, MD

Pediatric Department A, Ha Emek Medical Center, Rappaport School of Medicine Technion, Haifa, Israel

A child suffered from herpes simplex virus encephalitis at the age of 6 months; a late relapse occurred 8.5 years after the initial episode, the longest latency period reported. Radiologic and autopsy findings suggest local reactivation of latent herpes simplex virus as the cause of relapse. All cases of late relapse of herpes simplex virus encephalitis in the last 15 years are reviewed, with emphasis on clinical characteristics and possible mechanisms.

Key Words: herpes simplex virus • encephalitis • reactivation

This version was published on March 1, 2008

Journal of Child Neurology, Vol. 23, No. 3, 344-348 (2008)
DOI: 10.1177/0883073807309243


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