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This version was published on April 1, 2008
Journal of Child Neurology, Vol. 23, No. 4, 421-424 (2008)
DOI: 10.1177/0883073807309232

Effects of Postnatal Dexamethasone Exposure on the Developmental Outcome of Premature Infants

Howard Needelman, MD

Munroe-Meyer Institute for Genetics and Rehabilitation, hneedelm{at}unmc.edu

Martha Evans, MSN, APRN

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Holly Roberts, PhD

Munroe-Meyer Institute for Genetics and Rehabilitation

Matthew Sweney, MD

Department of Pediatrics University of Nebraska Medical Center, Omaha, Nebraska

J.B. Bodensteiner, MD

Pediatric Neurology, Barrow's Neurologic Institute, St. Joseph Hospital, Phoenix, Arizona

Extremely low birth weight premature infants are at risk for poor neurodevelopmental outcome. Postnatal dexamethasone has often been used in premature infants to prevent or treat bronchopulmonary dysplasia, and this drug is thought by some to affect neurodevelopmental outcome. We retrospectively examined the effect of this steroid on early neurodevelopment. Dexamethasone exposure was associated with an adverse outcome and was a stronger predictor of outcome than other accepted risk factors. If used, dexamethasone should be used in these high-risk infants for as short a period as possible.

Key Words: developmental outcome • dexamethasone • premature infant


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