Journal of Child Neurology

 

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Journal of Child Neurology, Vol. 23, No. 4, 459-462 (2008)
DOI: 10.1177/0883073807309252

Multiple Intracranial Tuberculomas Associated With Partial Status Epilepticus and Refractory Infantile Spasms

Catherine Zorn-Olexa, MD

Department of Pediatrics, Strasbourg-Hautepierre University Hospital, Strasbourg, France

Vincent Laugel, MD

Department of Pediatrics, Strasbourg-Hautepierre University Hospital, Strasbourg, France, vincent.laugel{at}chru-strasbourg.fr

Anne de Saint Martin, MD

Department of Pediatrics, Strasbourg-Hautepierre University Hospital, Strasbourg, France

Lionel Donato, MD

Department of Pediatrics, Strasbourg-Hautepierre University Hospital, Strasbourg, France

Michel Fischbach, MD, PhD

Department of Pediatrics, Strasbourg-Hautepierre University Hospital, Strasbourg, France

We report the case of a 10 month-old girl presenting with multiple intracranial tuberculomas associated with partial status epilepticus and cerebrovascular accident in the left sylvian territory. She later developed paradoxical enlargement of the tuberculomas during antituberculous treatment and severe neurological sequelae with refractory infantile spasms. The development of infantile spasms in this context is particularly remarkable, and this case is illustrative of the complex interrelationship between intracranial lesions, partial status epilepticus, and infantile spasms. It also highlights the difficult diagnosis of cerebral tuberculomas in infants and further supports the need for continued vigilance in industrialized countries.

Key Words: intracranial tuberculomas • status epilepticus • infantile spasms


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